Bindarit
- Product Name
- Bindarit
- CAS No.
- 130641-38-2
- Chemical Name
- Bindarit
- Synonyms
- AF 2838;CS-1989;Bindarit;Bindarit (AF2838);AF2838;AF-2838;AF 2838;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid;Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-
- CBNumber
- CB91118288
- Molecular Formula
- C19H20N2O3
- Formula Weight
- 324.37
- MOL File
- 130641-38-2.mol
Bindarit Property
- Boiling point:
- 542.9±40.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- solubility
- DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
- form
- A crystalline solid
- pka
- 3.59±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11479
- Product name
- Bindarit
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 11479
- Product name
- Bindarit
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $88
- Updated
- 2024/03/01
- Product number
- 11479
- Product name
- Bindarit
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 11479
- Product name
- Bindarit
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $250
- Updated
- 2024/03/01
- Product number
- 003975
- Product name
- Bindarit
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
Bindarit Chemical Properties,Usage,Production
Description
Bindarit is an inhibitor of monocyte chemoattractant protein (MCP) production that is selective for MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8 over other chemokines. It inhibits LPS- or C. albicans-induced production of MCP-1/CCL2 in isolated human monocytes (IC50s = 172 and 403 μM, respectively). Bindarit downregulates NF-κB signaling and prevents p65 and p65/p50-mediated MCP-1/CCL2 promoter activation in RAW264.7 cells. It delays the onset of proteinuria and prolongs survival in a mouse model of experimental lupus nephritis when administered at a dose of 50 mg/kg. It prevents LPS-induced increases in MCP-1/CCL2 expression in mouse brain and spinal cord when administered at a dose of 200 mg/kg and reduces the incidence and severity of experimental autoimmune encephalomyelitis (EAE) in mice. Bindarit is also a noncompetitive inhibitor of monocarboxylate transporter 4 (MCT4; Ki = 30.2 μM for the human transporter) that is selective for MCT4 over MCT1.
Uses
Bindarit shows anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines. Bindarit is a also protein antidenaturant agent. Bindarit modulates the NFkB pathway and has been shown to reduce secondary phase of adjuvant arthritis in rats.
Uses
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.